• Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli 

      Podnecky, Nicole L.; Aarag, Elizabeth; Kloos, Julia Maria; Sørum, Vidar; Primicerio, Raul; Roberts, Adam Paul; Rozen, Daniel E.; Samuelsen, Ørjan; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-10)
      There is urgent need to develop novel treatment strategies to reduce antimicrobial resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases susceptibility to other drugs, might enable selection against resistance during treatment. However, the success of this approach would depend on the conservation of CS networks across genetically diverse bacterial strains. Here, ...
    • Steady at the wheel: Conservative sex and the benefits of bacterial transformation 

      Ambur, Ole Herman; Engelstädter, Jan; Johnsen, Pål Jarle; Miller, Eric L.; Rozen, Daniel E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-12)
      Many bacteria are highly sexual, but the reasons for their promiscuity remain obscure. Did bacterial sex evolve to maximize diversity and facilitate adaptation in a changing world, or does it instead help to retain the bacterial functions that work right now? In other words, is bacterial sex innovative or conservative? Our aim in this review is to integrate experimental, bioinformatic and ...